Tadalafil 5 mg: A Closer Look at Its Significance

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Gui í a de Salud Masculina

  1. I. Pharmacological action
  2. II. Application
  3. Third, the method of taking
  4. IV. matters needing attention

tadalafil (tadalafil) 5mg is a drug dose specification for the treatment of erectile dysfunction (ED) and benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms.

I. Pharmacological action

1 、Mechanism of action on erectile dysfunction

Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor. During sexual stimulation, neurons in the penile sponge release nitric oxide (NO). NO activates guanylate cyclase and increases cyclic guanosine monophosphate (cGMP) synthesis.

Tadalafil 5 mg: A Closer Look at Its Significance

-PDE5 degrades cGMP, while tadalafil increases cGMP levels by inhibiting the activity of PDE5, causing smooth muscle relaxation and blood flow into penile tissue, resulting in an erection.

2 、Effect on lower urinary tract symptoms associated with benign prostatic hyperplasia

-there is PDE5 enzyme in prostate and bladder neck. after tadalafil inhibition, it can relax the smooth muscle of prostate and bladder neck and improve the lower urinary tract symptoms caused by benign prostatic hyperplasia, such as frequent urination, urgent urination, inexhaustible urination and so on.

II. Application

1 、impotence

It is suitable for male patients with erectile dysfunction, regardless of whether the etiology is organic, psychological or mixed.

-patients taking tadalafil 5mg as needed or regularly before sexual activity may improve erectile function.

2 、Lower urinary tract symptoms associated with benign prostatic hyperplasia

Tadalafil 5mg can kill two birds with one stone in patients with both erectile dysfunction and benign prostatic hyperplasia-related lower urinary tract symptoms. For patients with simple lower urinary tract symptoms, regular use of tadalafil 5mg can also help relieve symptoms.

Third, the method of taking

1 、Take as needed

For patients with erectile dysfunction, tadalafil 5mg can be taken as needed about 30 minutes-1 hour before sexual activity, but tadalafil may be effective within 36 hours after taking it, which lasts longer than other PDE5 inhibitors.

2 、Take it regularly once a day

-patients who want to improve erectile function and have more stable lower urinary tract symptoms associated with benign prostatic hyperplasia can choose to take tadalafil 5mg regularly once a day, which can maintain a stable blood concentration in the body and continuously improve the symptoms.

IV. matters needing attention

1 、Contraindication

-patients who are taking any form of nitrates (such as nitroglycerin, isosorbide dinitrate, etc.) prohibit tadalafil, as combination of nitrates with tadalafil can lead to a sharp drop in blood pressure, which can be life-threatening.

-it is forbidden for people who are allergic to tadarafi.

2 、Adverse reaction

Common adverse reactions include headache, facial flushing, indigestion, back pain, myalgia, etc. These adverse reactions are usually mild to moderate and relieve themselves after the drug effect disappears.

-in a few cases, adverse reactions such as blurred vision, eye pain and hearing loss may occur. If these conditions occur, you should seek medical attention in time.

3 、Interaction with other drugs

Tadalafil in combination with alpha-blockers (commonly used in the treatment of benign prostatic hyperplasia and hypertension) may increase the risk of hypotension. If necessary, the dose should be carefully adjusted under the guidance of a doctor.

-when combined with CYP3A4 inhibitors such as certain antifungal drugs (such as ketoconazole, itraconazole) and certain antibiotics (such as erythromycin, clarithromycin), the blood concentration of tadalafil may increase, increasing the risk of adverse reactions, and the dose needs to be adjusted or used with caution.


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